President Trump on Monday signed an executive order creating the Genesis Mission, a national initiative designed to remake America’s scientific enterprise by embedding advanced artificial intelligence across federal research programs.
The order directs the Department of Energy to build a closed-loop AI experimentation platform that links the nation’s supercomputers, laboratory networks, and federal data into a unified system capable of generating scientific foundation models and operating robotic labs. The Secretary of Energy is tasked with mobilizing the National Laboratories to pool computing power, data, and top scientific talent, while the Assistant to the President for Science and Technology coordinates the integration of federal research infrastructure. The initiative also brings in academic and private-sector partners through a collaboration between DOE, the APST, and the Special Advisor for AI & Crypto.
The Genesis Mission will concentrate on high-impact fields tied to national, economic, and health security, including biotechnology, critical mineral development, nuclear fission and fusion, space exploration, quantum science, and semiconductor and microelectronics research.
The administration says the effort is intended to reverse decades of declining research productivity despite growing federal budgets. Officials argue that AI can design experiments, generate new datasets, and model protein structures or advanced materials far faster than traditional methods, compressing timelines that once spanned years into weeks or months.
The Mission leverages the vast, organized data repositories and computing resources already housed within DOE labs to create a shared platform for federal agencies and U.S. innovators to pursue breakthroughs and secure America’s lead in the global AI race.
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